Genetic Environments of Plasmid-Mediated blaCTXM-15 Beta-Lactamase Gene in Enterobacteriaceae from Africa

The most widely distributed blaCTX-M gene on a global scale is blaCTX-M-15. dissemination has been associated with clonal spread and different types of mobile genetic elements. objective this review was to describe the environments blaCTX-M-15 detected from Enterobacteriaceae in published literature Africa. A search for relevant articles performed through PubMed, AJOL, Google Scholar electronic databases; 43 17 African countries were included based eligibility criteria. Insertion sequences reported as part environment 32 studies, integrons 13 plasmids 23 studies. In review, five insertion including ISEcp1, IS26, orf447, IS903, IS3 have which are Seven patterns seen environment. sequence ISEcp1 commonly located upstream end gene, while orf477 downstream. some truncated by IS26 IS3. class 1 integron (Intl1) be (13 studies), Intl1/dfrA17–aadA5 being common cassette array. IncFIA-FIB-FII multi-replicons IncHI2 replicon plasmid that horizontally transferred gene. Aminoglycoside-modifying enzymes, plasmid-mediated quinolone resistance genes collocated plasmids. This revealed predominant role Intl1 IncF mobilization continental